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Advanced Analytical Chemistry

Course Code: NCL 210


  • To familiarize all entering Ph.D. students, especially those with non-analytical background, to the basics of chemical analysis.
  • This course would also prepare students for more specialized courses in instrumental analysis.
  • Fundamental concepts in analytical chemistry and general overview of specialized instrumental analysis commonly used will be covered.

Pre-requisite: M.Sc. in any area with a good understanding of advanced undergraduate level chemistry and basic physics.

Class requirements:

This is an introductory level course. The subject matter will begin at a level that most chemists, physicists and biologists will be comfortable. At the end of the course, students will be able to appreciate and trouble shoot individual analytical problems and instrumentation in their day-to-day research. Continuous evaluation will be based on regular class quizzes, take home assignments and possibly a term paper or presentation. All the students are expected to have access to a computer with internet and a word processor (should be used for all assignments that will be submitted electronically).

Duration: 13 weeks

Number of lectures: 26 (90 minutes each, two lectures per week)

Course content:


No. of lectures

Introduction, recap of chemical equilibrium, errors and basic statistics in analysis, sample preparation, quantitation and calibration methods.


Analytical instrumentation, basic electronics, signal and noise.


Overview of optical methods of analysis: Components of optical instruments, atomic and molecular spectrometry based on absorption, emission and scattering.


Electroanalytical techniques (basic electrochemistry, voltammetry, potentiometry)


Analytical separations and (Introduction to chromatographic methods, GC, LC, electromigration techniques, hyphenated techniques and detectors)


Mass spectrometry


Practical session(s), demonstration and tour of a few instrumental facilities



Reference materials:

  1. Fundamentals of Analytical Chemistry, Douglas A. Skoog and Douglas M. West
  2. Instrumental Analysis by Douglas A. Skoog et. al.
  3. Quantitative Chemical Analysis, Daniel C. Harris (7th or latest edition)
  4. Chromed series by R.P.W. Scott: (E-books can be downloaded free of cost from



Attendance – 5%

Assignments – 50%

Mid-term exam – 20%

Final exam – 25%

Grades: A, B, C, D, F (fail)