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Mass Spectometry

Course Code: NCL 304


  • To equip advanced students with a thorough understanding of mass spectrometric methods of analysis. The course will also train students to utilize these techniques to solve complex analytical and bioanalytical problems.
  • This course also involves developing a project proposal using chromatographic techniques (course code 305) and mass spectrometry. Students are encouraged to take both 304 and 305 together for maximum benefit and appreciation.

Pre-requisite: Successful completion of “Fundamentals of analytical chemistry” or “Advanced Analytical Chemistry” or some level of demonstrated practical experience in broad analytical areas.

Class requirements: This will be a rigorous course at an intermediate to advanced level and the students will be expected to spend considerable amount of time reading and using chromatographic/mass spectral instrumentation. Students will ultimately work as a team on developing a proposal idea(s) using the class as a forum. Fundamental aspects of analysis including quantitative analysis will not be covered and the students will be expected to take off from where the 200 level analytical chemistry course ends. Continuous evaluation will be based on short quizzes, assignments, term papers, presentations and successful project conceptualization as well as proposal completion.

Duration: 13 weeks (2 Lecture hours a week)

Broad areas covered:

Mass Spectometry (Ionization sources CI, EI, LDI, ESI, DESI, ambient pressure techniques, SIMS), Mass analyzers (Quadrupole, traps, time-of-flight tubes, magnetic sector, tandem analyzers) and detectors; New developments in Mass spectrometry, analysis of complex biological and environmental and surface chemistry samples;

Student presentations, class/group project, practical session(s), demonstration and tour of a few instrumental facilities.

Reference materials:

Assorted research and review articles, online resources, and a few book chapters will be suggested at the beginning of the course.

 Evaluation and Grades: As per AcSIR guidelines